Molecular Formula | C7H4F3NO3 |
Molar Mass | 207.11 |
Density | 1.629g/cm3 |
Melting Point | 165-167°C |
Boling Point | 372.484°C at 760 mmHg |
Flash Point | 179.072°C |
Vapor Presure | 0mmHg at 25°C |
Storage Condition | Inert atmosphere,Room Temperature |
Refractive Index | 1.512 |
uses | 2-hydroxy-6-trifluoromethylnicotinic acid is an important pharmaceutical intermediate, mainly used in medicine, food, feed and other fields, can also be used as intermediates of fungicides. |
preparation | step 1, in a three-necked flask of 250ml, 10g of 2-hydroxy-6-trifluoromethylnicotinonitrile, 16.2g of phosphorus pentachloride and 40g of phosphorus oxychloride were added, heated to 100 ° C., followed by HPLC. The reaction lasted for 6 hours, it was added to ice water, extracted with dichloromethane, and the organic phase was dried, suction filtered and rotary dried to obtain 9.2g of solid 2-chloro-6-trifluoromethylnicotinonitrile with a purity of 93%. MS(EI)M 206(80.61)(M 2) 208(25.32). Step 2: 1g of 2-chloro-6-trifluoromethylnicotinonitrile and 1.9g of 40% sulfuric acid prepared in step 1 were added to a 50ml single-necked flask, oil bath heating 100 ℃, with HPLC tracking, reaction 4 days, raw material reaction, cooling, adding ice water, ethyl acetate extraction, spin dry, 0.88g of 2-hydroxy-6-trifluoromethylnicotinic acid were obtained as a yellow solid with a purity of 95.6%. MS(EI)M 207(37.64). |